accumulation in chronic kidney disease
نویسنده
چکیده
The project has progressed according to the original research plan with the most significant findings detailed in Aim 2 demonstrating the anti-fibrotic potential of cysteamine. Current efforts are focused on the investigating the effect of cysteamine on myofibroblasts, the primary cell producing extracellular matrix during kidney fibrosis. Furthermore, in our investigation of fibrogenic mechanisms in nephropathic cystinosis, we have discovered that CTNS-/macrophages are skewed to a pro-fibrotic phenotype and is the subject of our recent CRF grant submission.
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